![]() ![]() 1 Protein bindingĬorticosteroids are generally bound to corticosteroid binding globulin 11 and serum albumin 12 in plasma. Total hydrocortisone has a volume of distribution of 39.82L, while the free fraction has a volume of distribution of 474.38L. 4Ī 20mg IV dose of hydrocortisone has an AUC of 1163☒77ng*h/mL. 4 Slow absorbers take up hydrocortisone at a rate of 0.361☐.255/h while fast absorbers take up hydrocortisone at a rate of 1.05☐.255/h. Hydrocortisone retention enemas are have a bioavailability of 0.810 for slow absorbers and 0.502 in rapid absorbers. Topical hydrocortisone cream is 4-19% bioavailable with a T max of 24h. 1 However, the pharmacokinetics of hydrocortisone can vary by 10 times from patient to patient. Oral hydrocortisone at a dose of 0.2-0.3mg/kg/day reached a mean C max of 32.69nmol/L with a mean AUC of 90.63h*nmol/L 1 A 0.4-0.6mg/kg/day dose reached a mean C max of 70.81nmol/L with a mean AUC of 199.11h*nmol/L. 10 High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. Glucocorticoids inhibit neutrophil apoptosis and demargination they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives they inhibit NF-Kappa B and other inflammatory transcription factors they promote anti-inflammatory genes like interleukin-10. 10 Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. 1, 6 Patients should stop taking the medication if irritation or sensitization occurs. 10 Hydrocortisone has a wide therapeutic index 8 and a moderate duration of action. Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes. Varicella-zoster virus acute retinal necrosis.Superficial infection of the external auditory canal with inflammation.Disseminated Pulmonary Tuberculosis (TB).Ingredientsġ% w/w hydrocortisone, white soft paraffin, cetomacrogol emulsifying wax, liquid paraffin, chlorocresol, and purified water. are going to apply the cream to your face, eyes or ano-genital region, or to broken or infected skin (including cold sores, acne, athlete's foot or chickenpox).Īlthough it is not a prescription medication it is always best to consult your doctor before taking.are allergic (hypersensitive) to hydrocortisone or any of the other ingredients of this medicine. ![]() Use the cream for a maximum period of one week.ĭo not use in children under 10 years without speaking to your doctor first. Adults (including the elderly) and children over 10 years oldĪpply sufficient cream once or twice a day to thinly cover the affected area and gently rub into the skin until it disappears. If symptoms persist after 7 days, consult your doctor. Wash your hands before and after applying Hydrocortisone Cream but if appying to the hands do not wash after application.
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